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VolitionRx Ltd. (VNRX) Reports Noteworthy Results from Pilot Study of Its Diagnosis Tests for Prostate Cancer

Earlier this week, VolitionRx reported significant results from a pilot study of use of its NuQ® tests for diagnosis of prostate cancer. The results of the trial showed that the tests were able to detect approximately 80 percent of prostate cancer cases. Notably, they also showed that in addition to their high prostate cancer detection rate, the company’s tests are also able to differentiate between colorectal and prostate cancer.

“This is a very exciting outcome for us as we continue the development of our NuQ tests,” said Dr. Jake Micallef, Chief Scientific Officer at VolitionRx. “To have proof that with the right panel combination, NuQ tests can distinguish between different types of cancer as well as healthy samples, is just what we’ve been working towards. Detection of two major cancers with a blood test is a major milestone and a sound basis on which to investigate further cancers for panels of NuQ tests that detect and distinguish cancer diseases.”

The NuQ tests are able to make this distinction via detection of levels of epigenetically altered circulating nucleosomes in each sample, the structure of which Volition has found to be different in the two different types of cancer. As an illustration, VolitionRx mentions that the “levels of circulating nucleosomes containing H3K9(Me)3 were elevated in colorectal cancer, but supressed in prostate cancer”. This is an indicator of the NuQ ELISA tests’ ability to detect both cancer types.

Dr. Micallef will be presenting a poster at The International Society of Oncology and Biomarkers Congress (ISOBM) in Barcelona, Spain. There he will share results of the latest study into the effectiveness of NuQ® assays as an initial screening tool in detecting colorectal and now prostate cancer.

VolitionRx is carrying out several clinical trials on the effectiveness of the NuQ® assays as a cancer diagnostic tool:

• A 4,800-patient retrospective study and an 11,000 patient prospective study into colorectal cancer at Hvidovre Hospital, University of Copenhagen, Denmark.
• A 2,000-patient prospective study that involves patients with the 20 most prevalent cancers at University Hospital in Bonn, Germany.
• A 250-patient study into colorectal cancer at CHU-UCL Mont Godinne Hospital, Belgium.

Another recent trial documented that VolitionRx’s NuQ assays were able to detect over 85 percent of colorectal cancer cases with over 85 percent specificity. This earlier study had taken samples from healthy subjects as well as patients recently diagnosed with colorectal cancer.

A life sciences company focused on developing blood-based diagnostic tests for different types of cancer, VolitionRx seeks to provide diagnostic tests as common and easy-to-use as mainstream as diabetes and cholesterol tests for patient and doctor use.

For more information, visit: www.volitionrx.com

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