Targeted Strategies for Today's Evolving Markets

MissionIR Blog

Check out some of our latest original content that was created and distributed as part of our ongoing collaborations with IR firms and other companies.

MissionIRNewsBreaks – Annovis Bio Inc. (NYSE: ANVS) Eyes Opportunities Beyond ‘Year of Significant Progress’

Annovis Bio (NYSE: ANVS), a clinical-stage drug platform company developing novel therapies for neurodegenerative diseases, was featured in a recent article that discussed the company’s year-end investor webcast, where it provided stakeholders with a comprehensive overview of 2024 milestones and strategic initiatives for 2025. The webcast also highlighted financial developments, including the securing of a $50 million At-The-Market (“ATM”) offering and ongoing strategic efforts to raise additional funds to support clinical trial development and long-term growth.

“2024 has been a year of significant progress for Annovis Bio, and we are excited about the opportunities ahead,” Dr. Maria Maccecchini, founder, president and CEO of Annovis Bio, was quoted as saying. “Our Phase 3 programs are designed to advance our understanding of neurodegeneration and bring us closer to delivering meaningful treatments that improve patients’ lives.”

To view the full article, visit https://ibn.fm/aqjQd

About Annovis Bio Inc.
Headquartered in Malvern, Pennsylvania, Annovis Bio is dedicated to addressing neurodegeneration in diseases such as AD and PD. The company’s innovative approach targets multiple neurotoxic proteins, aiming to restore brain function and improve the quality of life for patients.

For more information, visit the company’s website at www.AnnovisBio.com, and social channels LinkedInX and YouTube.

NOTE TO INVESTORS: The latest news and updates relating to ANVS are available in the company’s newsroom at https://ibn.fm/ANVS

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Annovis Bio Inc. ANVS | Leave a comment

Thumzup Media Corp. (NASDAQ: TZUP) Expands into Vibrant South Florida Market as Part of Broader Growth Strategy

  • Thumzup Media Corporation, a company at the forefront of modernizing the social media branding and marketing industry, just announced its strategic expansion into South Florida
  • This marks a milestone for the company as it moves to become a leader in digital marketing, and the only platform that makes it easy for any brand or business to pay people cash to post about that brand or business to their personal friends on their personal social media
  • Thumzup anticipates a growing market share within its first year in the region and looks to replicate its tried and tested approach that has so far attracted over 500 advertisers and paid over $250,000 to social media users

Thumzup (NASDAQ: TZUP) is a leading provider of innovative social media branding and marketing solutions, which allow businesses and brands to pay customers and fans cash through Venmo and PayPal for their posts on social media. Thumzup is democratizing the multi-billion-dollar social media branding and marketing industry. Its flagship product, the Thumzup platform, utilizes a robust programmatic advertiser dashboard coupled with a consumer-facing app to enable individuals to get paid cash for posting about participating advertisers on major social media outlets through the Thumzup App. The easy-to-use dashboard allows advertisers to programmatically customize their campaign. Cash payments are made to app users/creators through Venmo and PayPal.

The company just announced its strategic expansion into South Florida. This marks a key milestone for the company, as it positions itself to tap into a market that has huge proven value (https://ibn.fm/EK9Xd). While making the announcement, Robert Steele, Thumzup’s CEO, acknowledged South Florida’s dynamic retail environment and how it aligns perfectly with the company’s marketing solutions. “South Florida represents a top-tier growth opportunity for Thumzup,” he noted. “Its vibrant retail environment, coupled with high consumer activity in Miami-Dade County, aligns perfectly with our programmatic marketing solutions. Our Nasdaq listing has supercharged our capabilities, enabling us to accelerate this expansion and provide greater value to our shareholders,” he added (https://ibn.fm/EK9Xd).

Thumzup anticipates growing market share within its first year in this region. It looks to achieve this by harnessing three main growth initiatives – strengthening partnerships with local businesses to enhance visibility and customer acquisition, expanding the network of gig economy workers, and increasing investment in data-driven marketing technology to maximize campaign efficiency and visibility.

The company’s proven approach has demonstrated its effectiveness in strengthening brand prominence and engagement, especially in high-demand markets. Seeing as it is the only company offering its unique value proposition in the way that it does, Thumzup has carved a niche and fleshed out its value proposition, attracting over 500 advertisers and paying social media users over $250,000 so far (https://ibn.fm/nN3Eb).

Tapping into the South Florida market positions Thumzup to tap into this lucrative market and grow its shareholder value. It also marks the first of many such initiatives, as it is an offshoot of the already robust base in West Los Angeles.

“Our expansion into South Florida not only positions Thumzup to tap into a lucrative market but also underscores our commitment to empowering local creators and businesses,” noted Mr. Steele. “We are dedicated to creating scalable solutions that drive value for all stakeholders, from shareholders to small business owners and gig economy workers,” he concluded (https://ibn.fm/EK9Xd).

For company information, visit www.ThumzupMedia.com.

NOTE TO INVESTORS: The latest news and updates relating to TZUP are available in the company’s newsroom at https://ibn.fm/TZUP

This email contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements are valid only as of today, and we disclaim any obligation to update this information. Actual results may differ significantly from management’s expectations. These forward-looking statements involve risks and uncertainties that include, among others, risks related to potential future losses, amount of, obtaining and satisfying terms of credit lines, competition, financing and commercial agreements and strategic alliances, seasonality, potential fluctuations in operating results and rate of growth, management of potential growth, system interruption, consumer and industry trends, limited operating history, and government regulation. In light of the significant uncertainties inherent in the forward-looking statements included herein, the inclusion of such information should not be regarded as a representation by the company or any other person that the objectives and plans of the company will be achieved.

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Thumzup Media Corp. TZUP | Leave a comment

MissionIRNewsBreaks – Clene Inc. (NASDAQ: CLNN) Receives FDA Roadmap on Potential Accelerated Pathway for CNM-Au8(R)

Clene (NASDAQ: CLNN) and its wholly owned subsidiary, Clene Nanomedicine Inc., a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, including amyotrophic lateral sclerosis (“ALS”) and multiple sclerosis (“MS”), recently received additional written guidance and a roadmap from the U.S. Food and Drug Administration’s (“FDA”) Division of Neurology 1 regarding a potential accelerated approval pathway for lead drug candidate CNM-Au8 in ALS. “The FDA guidance on a potential path to meet the regulatory standard for substantial evidence of effectiveness supporting accelerated approval came following an in-person Nov. 1 Type C meeting with the DN1 where the company presented additional clinical trial data and analyses. The FDA recommended that Clene leverage additional Neurofilament Light (‘NfL’) data from its three Expanded Access Programs (‘EAPs’) to support earlier findings,” reads an article discussing the guidance.

“Together with the survival and supportive biomarker data generated thus far, the drug’s benign safety profile, and the emerging EAP NfL data, we look forward to continued discussions with the Agency,” said Clene’s CEO and President, Rob Etherington. “Clene plans to include the additional data in an NDA submission under the accelerated approval pathway in mid-2025. We remain dedicated to the ALS community and honored to help critically ill patients and their families.”

To view the full article, visit https://ibn.fm/t0uHn

About Clene Inc.
Clene (along with its subsidiaries, “Clene”) and its wholly owned subsidiary Clene Nanomedicine Inc., is a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson’s disease and multiple sclerosis. CNM-Au8® is an investigational first-in-class therapy that improves central nervous system cells’ survival and function via a mechanism that targets mitochondrial function and the NAD pathway while reducing oxidative stress. CNM-Au8® is a federally registered trademark of Clene Nanomedicine, Inc. The company is based in Salt Lake City, Utah, with R&D and manufacturing operations in Maryland. For more information, please visit www.Clene.com.

NOTE TO INVESTORS: The latest news and updates relating to CLNN are available in the company’s newsroom at https://ibn.fm/CLNN

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Clene Inc. CLNN | Leave a comment

MissionIRNewsBreaks – Thumzup Media Corp. (NASDAQ: TZUP) Reports Strong Growth and Strategic Expansion into South Florida

Thumzup (NASDAQ: TZUP), a rising leader in social media branding and programmatic marketing, continues to demonstrate robust growth, with its advertiser base surpassing 600, just weeks after exceeding 500. The company attributes this success to its innovative platform, which empowers advertisers to connect with diverse audiences through authentic, user-generated content while offering monetary incentives to app users. Recent integrations with X (formerly Twitter) and a partnership with Tedras Global Solutions to leverage AI further enhance Thumzup’s ad targeting and campaign optimization capabilities, solidifying its disruptive position in the digital advertising landscape.

Building on this momentum, Thumzup has strategically expanded into South Florida, targeting high-growth areas like Miami, Fort Lauderdale, and West Palm Beach. Leveraging its Nasdaq debut to fuel expansion, the company aims to tap into the region’s multi-billion-dollar advertising market, vibrant retail activity, and rising consumer demand. By fostering partnerships with local businesses, empowering gig economy workers to promote brands, and investing in data-driven marketing technology, Thumzup plans to drive scalable growth and economic impact. As a member of the Miami Beach Chamber of Commerce, Thumzup has already begun forging connections with potential advertisers, reinforcing its commitment to empowering creators and businesses in this dynamic region.

To view the full press release, visit https://ibn.fm/P3nzQ

About Thumzup®

Thumzup Media Corporation is democratizing the multi-billion dollar social media branding and marketing industry. Its flagship product, the Thumzup platform, utilizes a robust programmatic advertiser dashboard coupled with a consumer-facing App to enable individuals to get paid cash for posting about participating advertisers on major social media outlets through the Thumzup App. The easy-to-use dashboard allows advertisers to programmatically customize their campaigns. Cash payments are made to App users/creators through PayPal and other digital payment systems.

Thumzup was featured on CBS Los Angeles and in KTLA.

NOTE TO INVESTORS: The latest news and updates relating to TZUP are available in the company’s newsroom at https://ibn.fm/TZUP

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Thumzup Media Corp. TZUP | Tagged | Leave a comment

Central Banks Are Hoarding Gold—Should You Follow Their Lead?

Central banks around the world have been ramping up their accumulation of gold, creating one of the most significant market shifts in years. Over the last two years, governments added over 2,000 tonnes of gold to their reserves (https://ibn.fm/U1IaY)—a pace not seen in the last 20 years.

While economic headlines often focus on inflation or interest rate cycles, this relentless accumulation of gold reveals something deeper: a global move to hedge against uncertainty and challenge the dominance of traditional reserve currencies like the U.S. dollar. For investors, it raises an obvious question—if the biggest financial institutions on the planet are loading up on gold, should you do the same?

The scale of buying is staggering. Central bank gold purchases hit 1,082 metric tons in 2022, a record-breaking year. In 2023, they followed with another 1,037 tonnes—the second-largest total ever recorded. This isn’t some short-lived trend driven by market momentum; it’s part of a calculated shift in global reserve strategy. Nations like China, Russia, Poland, and India are leading the charge. Poland’s central bank, for example, has added 42 metric tons to its holdings this year alone, pushing its gold reserves up to 420 metric tons. The bank’s governor has explicitly stated that gold will eventually account for 20% of Poland’s reserves—an unmistakable vote of confidence in the metal’s long-term role.

India, too, is stacking gold month after month, with its total reserves now reaching 854 metric tons, up 6% from just last year. China, after an 18-month buying spree that helped push gold prices to record highs, has paused purchases for the moment, but its overall accumulation remains critical. This trend is no accident. For many countries, holding gold has become a hedge not only against inflation but also against geopolitical risks and sanctions.

The freezing of Russia’s foreign assets in 2022 sent shockwaves through the global financial system. It demonstrated, in clear terms, the risks nations take by holding too much in foreign-denominated reserves. Gold, by contrast, is politically neutral. It cannot be sanctioned, frozen or inflated away by monetary policies. This is a major reason why countries wary of U.S. and European influence—like China and Russia—are turning to gold as a tool for economic sovereignty.

But central banks aren’t the only players benefiting from this trend. Their buying spree has created a massive tailwind for the broader gold market. Prices have already responded, and with more institutions expected to increase their reserves, that momentum is unlikely to fade anytime soon.

This dynamic presents an important opportunity for investors. While central banks accumulate physical bullion as a long-term safeguard, gold mining companies stand to profit significantly from this growing demand. The connection is straightforward: rising gold prices, fueled by institutional and central bank buying, directly improve margins for gold producers. Miners with proven reserves, efficient operations, and strong financials are particularly well-positioned to benefit as gold solidifies its role in the global financial system.

This brings us to McEwen Mining Inc. (NYSE: MUX) (TSX: MUX). Unlike central banks, retail investors don’t have the luxury of purchasing tonnes of gold to hedge against inflation or economic uncertainty—but they can still benefit from the same forces driving this trend. Gold mining stocks often deliver outsized returns during bull markets.

With strong production numbers and a growing resource base, McEwen Mining is well-positioned to ride the tailwinds of increasing gold demand. As central banks build their reserves, the global appetite for gold isn’t just stabilizing prices; it’s setting the stage for companies like this one to thrive.

Central banks aren’t making these moves lightly. Their gold-buying binge reflects a deeper understanding of the world’s shifting economic order—one where gold is more critical than ever as a hedge against risk. For investors looking to protect and grow their portfolios, following their lead might just make sense. And with McEwen Mining, you have a chance to align with the very forces reshaping the global financial system.

McEwen Mining: Positioned to Capitalize on Rising Gold Demand

As central banks continue their gold-buying spree, companies like McEwen Mining are positioned to benefit directly from rising demand and strong gold prices. Led by industry veteran Rob McEwen, the company has strategically built a diverse portfolio of gold, silver and copper assets across multiple mining jurisdictions, offering investors exposure to both current production and significant growth opportunities.

Strong Production and Financial Momentum

McEwen Mining has demonstrated improving operational performance in recent quarters. In Q3 2024, the company reported a 43% increase in gold production at its flagship Gold Bar Mine in Nevada—a result of improved mine operations and access to higher-grade ore (https://ibn.fm/vtVbb). This production boost contributed to a 36% increase in revenue.

Future Growth

Beyond current production, McEwen Mining’s growth story is strengthened by its pipeline of high-potential projects. Notably, the Fox Complex in Timmins, Ontario, has shown strong promise, with ongoing exploration uncovering new high-grade gold zones (https://ibn.fm/omhKE). The Fox Complex’s Grey Fox Project, in particular, continues to advance with meaningful production upside anticipated over the coming years.

At the same time, McEwen Mining’s 46.4% stake in McEwen Copper positions the company for long-term growth in the broader metals market (https://ibn.fm/jaGnO). McEwen Copper’s Los Azules project is currently ranked as the 8th largest undeveloped copper resource globally, with significant value potential as global demand for copper accelerates due to infrastructure spending and renewable energy trends.

Why MUX Stands Out

The company’s financial position is supported by higher gold prices. With Rob McEwen personally holding 17% of the company’s shares, investors can take confidence in a leadership team with skin in the game and a clear focus on delivering shareholder value. In fact, his investment in MUX and McEwen Copper now totals more than $225 million and he takes an annual salary of only $1.

Conclusion

As gold solidifies its role as a hedge against economic and geopolitical uncertainty, McEwen Mining represents an opportunity for investors looking to capitalize on central bank gold demand. The company combines current production growth and exploration upside—a rare mix that positions it to thrive in a bullish gold market.

For investors seeking exposure to gold without purchasing physical bullion, McEwen Mining offers a clear advantage, driven by its expanding production profile and ambitious growth plans. As central banks reshape the global financial landscape through their gold-buying binge, companies like McEwen Mining are well-positioned to deliver in the years ahead.

For more information, visit the company’s website at www.McEwenMining.com.

NOTE TO INVESTORS: The latest news and updates relating to MUX are available in the company’s newsroom at http://ibn.fm/MUX

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in McEwen Mining Inc. MUX | Leave a comment

Clene Inc. (NASDAQ: CLNN) Improves Cash Position and Runway with New Debt Facility for CNM-Au8(R) Data Collection to Support Accelerated Approval Application

  • The $10 million loan agreement, carrying a 12% interest rate and secured by all assets of Clene, was signed with three lenders affiliated with the company.
  • The funds will be used to repay the remaining $7.9 million debt of an Avenue Capital Group loan, and will improve the company’s cash position, enabling it extra runway to generate additional data to support the new drug application of CNM-Au8 for ALS.
  • The FDA earlier suggested that Clene leverage additional neurofilament light (“NfL”) data from the company’s three Expanded Access Protocols (compassionate use programs) and the HEALEY ALS Platform Trial to support earlier clinical trial findings, with a follow-up meeting with the FDA to be held in early 2025.

Clene (NASDAQ: CLNN) and its wholly owned subsidiary, Clene Nanomedicine Inc., is a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, including amyotrophic lateral sclerosis (“ALS”) and multiple sclerosis (“MS”). The company has now secured a new $10 million debt facility, enabling the pay-off of another loan at higher interest rates to significantly improve its cash position as well as finance operations to generate of additional data to support the new drug application of lead drug candidate CNM-Au8 for ALS (https://ibn.fm/Maor9).

The new debt facility was signed with three entities affiliated with Clene and was closed on Dec. 20, 2024. Under the terms of the deal, the three lenders provided the aggregate principal amount of $10 million for the secured, partially convertible debt facility, with a fixed interest rate of 12% and a maturity eighteen months after closing. The first 12 twelve months are interest-only. Sixty-five percent of the debt facility is convertible into shares at a fixed conversion price of $5.67, a 130% premium to Clene’s closing stock price on the day of signing.

The funding will be used to pay off the remaining debt of an existing senior loan taken with Avenue Venture Opportunities Fund, L.P., a fund of the Avenue Capital Group, in May 2021. Over the course of the loan agreement, Clene borrowed $20 million. Repayment under the loan agreement began in July 2024 with $7 million of principal outstanding as of December 2024 plus a final payment fee of $0.85 million, for a total payoff of approximately $7.9 million, including a prepayment penalty.

The new loan will help improve the company’s cash position, enabling the cash runway to generate additional biomarker data to support the new drug application of CNM-Au8 for ALS via an accelerated regulatory pathway. The company met with the U.S. Food and Drug Administration (“FDA”) to discuss a potential accelerated regulatory pathway in November and has since received additional guidance from the regulatory body to gather further clinical trial data.

CNM-Au8, an oral suspension of gold nanocrystals, works by improving cellular energy production and utilization, which is critical for maintaining neuronal health. The drug candidate has already been shown to improve central nervous system cells’ survival and function via a mechanism that targets mitochondrial function and the nicotinamide adenine dinucleotide (“NAD”) pathway while reducing oxidative stress. Phase 2 clinical trial data, as presented to the FDA, revealed significant improvement in survival rates, functional status and combined assessment of function and survival.

The FDA recommended that Clene leverage additional NfL data from its three expanded access protocols (“EAPs”) and the HEALEY ALS Platform Trial to support earlier findings. Clene will have another meeting with the FDA in early 2025 to review and finalize its analysis plan for the EAP NfL biomarker analyses.

Commenting on the new debt facility, Clene CEO and President Rob Etherington said the company was grateful for the trust of its long-standing investors who remain supportive of the company’s efforts to provide potentially lifesaving therapies for ALS and other neurodegenerative diseases.

“We believe that the proceeds from this new debt facility, including an extended interest-only period, will allow Clene the cash runway to generate the additional data the U.S. Food and Drug Administration has requested from our expanded access programs,” Etherington added. “The data are being gathered to support the existing clinical study data for inclusion in an application seeking approval of CNM-Au8 for ALS through the accelerated regulatory pathway.”

For more information, visit the company’s website at www.Clene.com.

NOTE TO INVESTORS: The latest news and updates relating to CLNN are available in the company’s newsroom at https://ibn.fm/CLNN

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Clene Inc. CLNN | Leave a comment

MissionIRNewsBreaks – Mullen Automotive Inc. (NASDAQ: MULN) Secures Class 3 EV Truck Order from Westland Floral

Mullen Automotive (NASDAQ: MULN) has received a purchase order for two Class 3 EV trucks, the Mullen THREE, from Westland Floral. The trucks, customized by Phenix Truck Bodies in California, were delivered through Pritchard Commercial and include California HVIP incentives, emphasizing cost and environmental benefits. The Mullen THREE, designed for urban last-mile delivery, boasts a 38-foot turning diameter, over 5,800 pounds of payload, and easy upfitting capabilities. Mullen’s EV lineup meets strict U.S. safety and emissions standards and offers substantial savings through state and federal incentive programs, including up to $45,000 in California rebates.

To view the full press release, visit https://ibn.fm/84JpC

About Mullen Automotive Inc.

Mullen Automotive is a Southern California-based automotive company building the next generation of commercial electric vehicles (“EVs”) with two United States-based vehicle plants located in Tunica, Mississippi, (120,000 square feet) and Mishawaka, Indiana (650,000 square feet). In August 2023, Mullen began commercial vehicle production in Tunica. In September 2023, Mullen received IRS approval for federal EV tax credits on its commercial vehicles with a Qualified Manufacturer designation that offers eligible customers up to $7,500 per vehicle. As of January 2024, both the Mullen ONE, a Class 1 EV cargo van, and Mullen THREE, a Class 3 EV cab chassis truck, are California Air Resource Board (“CARB”) and EPA certified and available for sale in the U.S. The CARB-issued HVIP approval on the Mullen THREE, Class 3 EV truck, provides up to a $45,000 cash voucher at time of vehicle purchase. The company has also recently expanded its commercial dealer network to seven dealers with the addition of Papé Kenworth. Other previously announced dealers include Pritchard EV, National Auto Fleet Group, Ziegler Truck Group, Range Truck Group, Eco Auto, and Randy Marion Auto Group, providing sales and service coverage in key Midwest, West Coast, Pacific Northwest, New England and Mid-Atlantic markets. The company has also announced Foreign Trade Zone (“FTZ”) status approval for its Tunica, Mississippi, commercial vehicle manufacturing center. FTZ approval provides a number of benefits, including deferment of duties owed and elimination of duties on exported vehicles. For more information about the company, visit www.MullenUSA.com.

NOTE TO INVESTORS: The latest news and updates relating to MULN are available in the company’s newsroom at https://ibn.fm/MULN

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Mullen Automotive Inc. MULN | Leave a comment

Thumzup Media Corp. (NASDAQ: TZUP) Targets Expanded Market Reach with X and TikTok Integration

  • Thumzup Media Corporation, a company at the forefront of modernizing the social media branding and marketing industry with its unique approach, looks to expand advertiser reach through strategic platform integration with X and TikTok
  • These strategic moves will complement the company’s current integration with Instagram, and will allow for unified campaign management to create and customize branded content across all the platforms
  • So far this year, Thumzup has realized a 202% growth in advertisers, underscoring the platform’s escalating appeal across diverse business sectors
  • The new integrations highlight the company’s commitment to maximize advertiser reach with their revolutionary approach of turning everyday users into brand ambassadors

Thumzup (NASDAQ: TZUP), a Los Angeles-based company that is disrupting the social media branding and marketing industry with its unique platform, designed to connect advertisers directly with everyday social media users, is looking to further expand its advertiser reach through strategic integrations with the two leading social media platforms, X (formerly Twitter) and TikTok. The launch with X is already underway (https://ibn.fm/R8doq), and TikTok upcoming (https://ibn.fm/5ieBW). These ambitious moves complement the company’s current integration with Instagram and will disrupt traditional advertising models, mainly through scalable user-driven content monetizationn (https://ibn.fm/vJoN8).

Such initiatives highlight Thumzup’s commitment to maximizing advertiser reach and turning everyday users into brand ambassadors. Today, the company is the only platform that makes it easy for any brand or business to pay people cash to share a brand or business with their personal friends on their social media. This overall market is currently valued at over $400 billion, and the approach has already allowed Thumzup to achieve a 202% growth in advertisers in 2024 alone, underscoring the platform’s escalating appeal across diverse business sectors.

With its X integration, Thumzup looks to expand its potential reach to a massive and engaged audience, ultimately positioning itself for continued growth in the digital advertising space. So far this year, X has experienced a 12.5% year-over-year (“YoY”) growth in time spent on the platform, with the numbers expected to grow as time progresses. Thumzup looks to tap into this growth, broadening its reach and amplifying its impact.

“Our planned integration with X Corp. marks a transformative milestone for Thumzup,” noted Thumzup’s CEO, Robert Steele. “Since our inception, Thumzup has aimed to expand to other social media platforms. Having achieved milestones such as paying out over $250,000 to our users with approximately 25,000 Instagram posts, and recently listing our company on Nasdaq, we are now aggressively moving forward to broaden our reach. We expect this integration to occur by the end of January 2025. Once implemented, it should significantly amplify Thumzup’s impact, enabling advertisers to leverage trusted user voices to drive scalable and authentic engagement,” he added (https://ibn.fm/vJoN8).

The integration will support unified campaign management to create and customize branded content for both X and Instagram. It will also offer enhanced audience targeting to boost campaign efficiency further. It will use monetization for users to revolutionize influencer marketing by enabling individuals to earn variable cash rewards for authentic brand endorsements.

Thumzup is taking on a similar approach with TikTok, a platform with over 1.5 billion active monthly users. The company looks to drive value creation with plans specifically designed to offer unified content management across the platform, alongside Instagram and X. The features will cover seamless multi-platform posting with a single post workflow. It will also feature campaign optimization and monetization through direct user compensation.

“Tapping into TikTok’s user engagement metrics is expected to be a game-changer,” noted Mr. Steele. “This planned integration will enhance our competitive advantage and establish our role in redefining modern digital advertising,” he added (https://ibn.fm/x3QNh).

“Our platform’s capability to engage consumers directly through social media and reward them for their endorsements has met with enthusiastic response from a wide spectrum of businesses,” stated Mr. Steele. “This includes retailers, restaurants, home furnishings, clothes, coffee shops, and consumer brands in beverages and breakfast cereals. The Thumzup platform is continuing to resonate with advertisers, and we are thrilled by the continued adoption of our platform,” he added (https://ibn.fm/AmEDd).

For company information, visit www.ThumzupMedia.com.

NOTE TO INVESTORS: The latest news and updates relating to TZUP are available in the company’s newsroom at https://ibn.fm/TZUP

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Thumzup Media Corp. TZUP | Leave a comment

AI is Being Trained to Spot Anomalies During Tests in the Medical Sector

Audra Moran, the head of a global charity (“OCRA”) focused on researching ovarian cancer, says her area of expertise is underfunded and very deadly. Most cases of this disease originate within the fallopian tubes and spread to the ovaries. The problem is, by the time the malignancy spreads to the ovaries, there is a high likelihood that it has also spread to other parts of the body. This is why early detection is critical as life-saving interventions can be carried out.

The life-changing window of detection is approximately 5 years before the onset of ovary cancer symptoms, but it is currently difficult to detect the condition within this period.

That is where artificial intelligence (“AI”) comes in. New testing techniques are exploring how AI can be leveraged to detect ovarian cancer early enough to make a difference in the mortality of patients. Other deadly infections, such as pneumonia, can also benefit from this AI-testing method.

Doctor Daniel Heller, a biomedical engineer based at the cancer center at Memorial Sloan Kettering in New York, heads a team developing technology to conduct blood tests using nanotubes. Nanotubes were discovered two decades ago, but how to leverage them during diagnostic tests had eluded scientists. Dr. Heller and his team are working to solve this challenge.

They took blood samples from two groups of patients; one group contained samples from people who have been diagnosed with ovarian cancer. The other group didn’t have the disease. This data was uploaded into an algorithm that uses machine learning to detect patterns within those blood samples. One challenge the team encountered was the limited data on ovarian cancer patients. This is because the condition is rare, and the patients who are diagnosed with the cancer are treated by different hospitals whose data isn’t readily available to research teams.

Dr. Heller says they took a chance and used data from just 100 patients to train their AI model. It was a desperate attempt, and they were pleasantly surprised to see that the AI model was able to perform more reliably than other biomarkers currently in use to detect the cancer.

He says the system is undergoing further development and it could be 3-5 years away from commercialization. Nevertheless, the team is hopeful that this AI model can be deployed to detect other gynecological disorders so that doctors can use the tool to positively identify which particular condition a patient is suffering from.

As more use cases of AI emerge, not just in the biomedical field but also in other walks of life, the demand for minerals like gold and copper that are critical in the burgeoning AI industry will increase. Companies like McEwen Mining Inc. (NYSE: MUX) (TSX: MUX) that focus their efforts on extracting these AI metals are well positioned for the future ahead.

NOTE TO INVESTORS: The latest news and updates relating to MUX are available in the company’s newsroom at http://ibn.fm/MUX

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in McEwen Mining Inc. MUX | Leave a comment

MissionIRNewsBreaks – Annovis Bio Inc. (NYSE: ANVS) Committed to Ensuring Highest Standards in Continued Buntanetap Trials

Annovis Bio (NYSE: ANVS) is a clinical-stage drug platform company developing novel therapies for neurodegenerative diseases. The company’s lead candidate, buntanetap, is an innovative drug that targets multiple pathways involved in neurodegenerative diseases by inhibiting the production of neurotoxic proteins that lead to the death of neurons, thereby slowing or stopping disease progression. A recent article highlights the company’s successful clinical trials and its receipt of FDA clearance to proceed with a pivotal phase 3 Alzheimer’s disease program for buntanetap, set to begin in early 2025.

“Our priority is to bring a safe and effective treatment to patients, and we are committed to ensuring the next clinical trials are executed at the highest standards to attain an expedited NDA submission,” Dr. Maccecchini said in a recent episode of IBNs’ BioMedWire Podcast.

To view the full article, visit https://ibn.fm/gLby4

About Annovis Bio Inc.
Headquartered in Malvern, Pennsylvania, Annovis Bio is dedicated to addressing neurodegeneration in diseases such as AD and PD. The company’s innovative approach targets multiple neurotoxic proteins, aiming to restore brain function and improve the quality of life for patients.

For more information, visit the company’s website at www.AnnovisBio.com, and social channels LinkedInX and YouTube.

NOTE TO INVESTORS: The latest news and updates relating to ANVS are available in the company’s newsroom at https://ibn.fm/ANVS

About MissionIR

MissionIR (“MIR”) is a specialized communications platform with a focus on assisting IR firms with syndicated content to enhance the visibility of private and public companies within the investment community. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers: (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries; (2) article and editorial syndication to 5,000+ outlets; (3) enhanced press release enhancement to ensure maximum impact; (4) social media distribution via IBN to millions of social media followers; and (5) a full array of tailored corporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, MIR is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MIR brings its clients unparalleled recognition and brand awareness.

MIR is where breaking news, insightful content and actionable information converge.

For more information, please visit www.MissionIR.com

Please see full terms of use and disclaimers on the MissionIR website applicable to all content provided by MIR, wherever published or re-published: https://www.MissionIR.com/Disclaimer

MissionIR
Los Angeles, CA
www.MissionIR.com
310.299.1717 Office
[email protected]

MissionIR is powered by IBN

Posted in Annovis Bio Inc. ANVS | Leave a comment